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Synthesis 1994; 1994(9): 953-956
DOI: 10.1055/s-1994-25612
DOI: 10.1055/s-1994-25612
paper
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A Simple, Convenient and General Method for the Synthesis of N-Acylalkylaminomethyl-and N-Acylalkylamino(alkyl, aryl, heteroaryl)methylphosphonates and -phosphine Oxides
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Publication History
Publication Date:
17 September 2002 (online)
A variety of N-acylalkylaminomethyl- and alkylamino(alkyl, aryl, heteroaryl)methylphosphonates and -phosphine oxides has been efficiently prepared by acylation of suitable Schiff bases and subsequent treatment of the chloromethylcarboxamide intermediates with the appropriate phosphorylating agent.