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Synlett 1994; 1994(7): 524-526
DOI: 10.1055/s-1994-22914
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Synthesis of 3-substituted but-3-enoic Acids via Palladium Catalysed Cross-Coupling Reaction of 3-iodobut-3-enoic Acid with Organometallic Reagents

Alain Duchêne* , Mohamed Abarbri, Jean-Luc Parrain, Masato Kitamura, Ryoji Noyori
  • *Laboratoire de Synthèse et d'Etudes Physicochimiques Organiques, Faculté des Sciences de Tours, Parc de Grandmont, 37200 Tours (France)
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Publication Date:
18 September 2002 (online)

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3-Substituted but-3-enoic acids can be obtained in good yields under mild experimental conditions by palladium-catalysed cross-coupling of 3-iodobut-3-enoic acid with organozinc or organotin compounds using PdCl2(MeCN)2 as catalyst and DMF as solvent.

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