A Convenient Method For The Synthesis Of N-Alkyl-Substituted  4-Hydroxy-1,2,3,4-tetrahydroisoquinolines

Gyula Simig; Manfred Schlosser

doi:10.1055/s-1990-20984

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Synlett 1990; 1990(1): 50-51
DOI: 10.1055/s-1990-20984

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A Convenient Method For The Synthesis Of N-Alkyl-Substituted 4-Hydroxy-1,2,3,4-tetrahydroisoquinolines

Gyula Simig^* , Manfred Schlosser

^*Institut de Chimie organique de l'Université, Rue de la Barre 2, CH-1005 Lausanne, Switzerland

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Publication Date:
08 March 2002 (online)

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The alkylation of secondary benzylamines and subsequent acid-catalyzed cyclization affords 2-alkyl-4-hydroxy-1,2,3,4-tetrahydroisoquinolines with good yields.

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