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CC BY 4.0 · Arq Neuropsiquiatr 2023; 81(12): 1030-1039
DOI: 10.1055/s-0043-1777721
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Reperfusion therapy for acute ischemic stroke: where are we in 2023?

Terapia de reperfusão para o acidente vascular isquêmico agudo: onde estamos em 2023?
Sheila Cristina Ouriques Martins 
1   Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Porto Alegre RS, Brazil.
2   Hospital Moinhos de Vento, Porto Alegre RS, Brazil.
,
Octávio Marques Pontes-Neto 
3   Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto SP, Brazil.
,
Arthur Pille 
1   Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Porto Alegre RS, Brazil.
2   Hospital Moinhos de Vento, Porto Alegre RS, Brazil.
,
Thaís Leite Secchi 
2   Hospital Moinhos de Vento, Porto Alegre RS, Brazil.
,
Maramélia Araújo de Miranda Alves 
4   Universidade Federal de São Paulo, Hospital São Paulo, São Paulo SP, Brazil.
,
Letícia Costa Rebello 
5   Hospital de Base de Brasília, Brasília DF, Brazil.
,
Jamary Oliveira-Filho 
6   Universidade Federal da Bahia, Salvador BA, Brazil.
,
Marcos Christiano Lange 
7   Universidade Federal do Paraná, Hospital de Clínicas, Curitiba PR, Brazil.
,
Gabriel R. de Freitas 
8   Hospital Quinta D'Or, Rio de Janeiro RJ, Brazil.
,
João Brainer Clares de Andrade 
4   Universidade Federal de São Paulo, Hospital São Paulo, São Paulo SP, Brazil.
,
Letícia Januzi de Almeida Rocha 
9   Hospital Universitário Professor Alberto Antunes, Maceió AL, Brazil.
,
Daniel da Cruz Bezerra 
10   Hospital Pró-Cardíaco, Rio de Janeiro RJ, Brazil.
,
Ana Claudia de Souza 
2   Hospital Moinhos de Vento, Porto Alegre RS, Brazil.
,
Leonardo Augusto Carbonera 
2   Hospital Moinhos de Vento, Porto Alegre RS, Brazil.
,
Raul Gomes Nogueira 
11   University of Pittsburgh, Pittsburgh PA, United States.
,
Gisele Sampaio Silva 
4   Universidade Federal de São Paulo, Hospital São Paulo, São Paulo SP, Brazil.
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Abstract

Over the last three decades, stroke care has undergone significant transformations mainly driven by the introduction of reperfusion therapy and the organization of systems of care. Patients receiving treatment through a well-structured stroke service have a much higher chance of favorable outcomes, thereby decreasing both disability and mortality. In this article, we reviewed the scientific evidence for stroke reperfusion therapy, including thrombolysis and thrombectomy, and its implementation in the public health system in Brazil.

Resumo

Nas últimas três décadas, o tratamento do AVC sofreu transformações significativas, impulsionadas principalmente pela introdução das terapias de reperfusão e pela organização dos serviços de AVC. Os pacientes que recebem tratamento em um serviço de AVC bem estruturado têm uma probabilidade muito maior de resultados favoráveis, diminuindo assim a incapacidade funcional e a mortalidade. Neste artigo, revisamos as evidências científicas para as terapias de reperfusão do AVC, incluindo trombólise e trombectomia e sua implementação no sistema público de saúde no Brasil.

Keywords

Stroke - Ischemic Stroke - Reperfusion - Thrombolytic Therapy - Thrombectomy

Palavras-chave

Acidente Vascular Cerebral - Acidente Vascular Cerebral Agudo - Reperfusão - Terapia Trombolítica - Trombectomia

Authors' Contributions

SM: conceptualization, data curation, methodology, project administration, writing – original draft, writing – review & editing; AP: investigation, writing – review & editing; TLS: writing – review & editing; OMPN, MAMA, GSS: data curation, validation, writing – review & editing; LCR, JOF, MCL, GRF, JBCA, LJAR, DCB, ACS, LAC, RGN: validation.




Publication History

Received: 06 November 2023

Accepted: 21 November 2023

Article published online:
29 December 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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