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CC BY 4.0 · Eur J Dent 2023; 17(04): 1241-1247
DOI: 10.1055/s-0042-1759489
Original Article

Association between Clinical/Radiographic Characteristics and Histopathological Diagnoses of Periapical Granuloma and Cyst

Danuchit Banomyong
1   Department of Operative Dentistry and Endodontics, Faculty of Dentistry, Mahidol University, Bangkok, Thailand
2   Dental Department, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok, Thailand
,
Raweewan Arayasantiparb 
3   Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand
,
Kanoknuch Sirakulwat
4   Faculty of Dentistry, Mahidol University, Bangkok, Thailand
,
Jane Kasemsuwan
4   Faculty of Dentistry, Mahidol University, Bangkok, Thailand
,
Nannaphat Chirarom
4   Faculty of Dentistry, Mahidol University, Bangkok, Thailand
,
Nithiporn Laopan
4   Faculty of Dentistry, Mahidol University, Bangkok, Thailand
,
Puangwan Lapthanasupkul 
5   Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand
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Abstract

Objective The aim of this study was to determine the association between clinical/radiographic characteristics and histopathological diagnoses of periapical granuloma and cyst obtained from the teeth treated with endodontic microsurgery.

Materials and Methods The clinical, radiographic (periapical and cone-beam computed tomography), and histopathological data were collected from patients' dental records of endodontic microsurgery on the teeth with periapical lesions. These lesions were histopathologically diagnosed as either granuloma or cyst, at the Endodontic Clinic, Faculty of Dentistry, Mahidol University, Bangkok, Thailand, from 2016 to 2021 according to inclusion and exclusion criteria. The data were analyzed using bivariate analysis and a multinomial logistic regression at a significance level of p-value less than 0.05.

Results A total of 83 patients (58 females and 25 males) with an average age of 45 to 49.5 years old met the criteria including 68 periapical granulomas (81.9%) and 15 periapical cysts (18.1%). A periapical lesion involving multiple teeth in a periapical radiograph was significantly associated with the histopathological diagnosis of periapical cyst (p < 0.05). Such periapical lesion was six times more likely to be periapical cyst than periapical granuloma.

Conclusions A significant factor for predicting periapical cyst from periapical granuloma was the presence of a periapical lesion with multiple-teeth involvement in a dental radiograph.

Keywords

dental radiograph - endodontic microsurgery - granuloma - histopathology - periapical cyst


Publication History

Article published online:
04 January 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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