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CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2023; 27(03): e423-e427
DOI: 10.1055/s-0042-1746193
Original Research

Outcomes of Endoscopic Sinus Surgery for Chronic Rhinosinusitis in Adults with Primary Ciliary Dyskinesia

Diogo Barreto Plantier 
1   Department of Otorhinolaryngology and Ophthalmology, School of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil
,
Fábio de Rezende Pinna 
1   Department of Otorhinolaryngology and Ophthalmology, School of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil
,
Mary Anne Kowal Olm 
2   Department of Pathology, School of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil
,
Rodrigo Athanázio 
3   Pulmonary Division, Instituto do Coração, School of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil
,
Renata Ribeiro de Mendonça Pilan 
1   Department of Otorhinolaryngology and Ophthalmology, School of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil
,
Richard Louis Voegels 
1   Department of Otorhinolaryngology and Ophthalmology, School of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil
› Author Affiliations Funding The author(s) did not receive financial support for the research. The author Diogo Barreto Plantier was a CNPQ doctoral scholarship holder.
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Abstract

Introduction Primary ciliary dyskinesia (PCD) is a rare inherited disease associated with impairment of mucociliary transport and, consequently, with a high incidence of chronic rhinosinusitis. For patients with chronic rhinosinusitis who remain symptomatic despite medical treatment, endoscopic sinus surgery is a safe and effective therapeutic option. However, to date, no studies have been found evaluating the effect of surgery on the quality of life associated with the effect on olfaction and nasal endoscopy findings of patients with primary ciliary dyskinesia and chronic rhinosinusitis.

Objective To describe the effect of endoscopic sinus surgery on the quality of life, on olfaction, and on nasal endoscopy findings of adults with PCD and chronic rhinosinusitis.

Methods Four patients who underwent endoscopic sinus surgery were included. The Sinonasal Outcome Test-22 (SNOT-22) score, the Nasal Obstruction Symptom Evaluation (NOSE) questionnaire, and the Lund-Kennedy score were collected preoperatively and at 3 and 6 months postoperatively. The olfaction as assessed with the University of Pennsylvania Smell Identification Test (UPSIT), which was administered preoperatively and 3 months postoperatively.

Results A total of 4 patients with a mean age of 39.3 years old (3 men and 1 woman) completed the study. All patients showed clinically significant improvement in the SNOT-22, NOSE, and Lund-Kennedy scores at 3 months postoperatively, and this improvement was sustained throughout the follow-up period. However, olfaction did not improve after surgery.

Conclusion The endoscopic sinus surgery treatment of chronic rhinosinusitis in adults with PCD was associated with improvement in quality of life and endoscopic findings. However, no improvement in olfaction was demonstrated. Studies with a larger number of patients and control groups should help confirm these findings.

Keywords

chronic rhinosinusitis - endoscopic sinus surgery - hyposmia - kartagener syndrome - paranasal sinuses - primary ciliary dyskinesia


Publication History

Received: 04 November 2021

Accepted: 01 March 2022

Article published online:
04 August 2023

© 2023. Fundação Otorrinolaringologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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