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CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2022; 32(02): 182-190
DOI: 10.1055/s-0042-1744138
Original Article

How Are Imaging Findings Associated with Exocrine Insufficiency in Idiopathic Chronic Pancreatitis?

Ranjan Shetty
1   Department of Radiology, Christian Medical College, Vellore, India
,
Gauri Kumbhar
2   Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India
,
Ajith Thomas
2   Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India
,
Benedicta Pearlin
1   Department of Radiology, Christian Medical College, Vellore, India
,
Sudipta Dhar Chowdhury
2   Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India
,
Anuradha Chandramohan
1   Department of Radiology, Christian Medical College, Vellore, India
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Abstract

Aim The aim is to study the association between imaging findings in chronic pancreatitis and fecal elastase 1 (FE1) in patients with idiopathic chronic pancreatitis (ICP).

Methods In this retrospective study on a prospectively maintained database of patients with ICP, a radiologist blinded to clinical and laboratory findings reviewed CT and/or MRI. Findings were documented according to recommendations of the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, October 2018. Low FE1 (<100 μg elastase/g) was considered diagnostic of pancreatic exocrine insufficiency (PEI). Association between imaging findings and FE1 was studied.

Results In total, 70 patients (M: F = 37:33) with ICP with mean age of 24.2 (SD 6.5) years, range 10 to 37 years and mean disease duration of 5.6 (SD 4.6) years, range 0 to 20 years were included. Mean FE level was 82.5 (SD 120.1), range 5 to 501 μg elastase/g. Mean main pancreatic duct (MPD) caliber was 7 (SD 4) mm, range 3 to 21 mm and mean pancreatic parenchymal thickness (PPT) was 13.7 (SD 5.5) mm, range 5 to 27 mm. There was a significant association between FE1 and MPD size, PPT, type of pancreatic calcification; presence of intraductal stones, side branch dilatation on magnetic resonance cholangiopancreatography and extent of pancreatic involvement (p <0.05). In total, 79%, 86%, and 78% with moderate to severe MPD dilatation, pancreatic atrophy, and side branch dilatation had low FE1, respectively. But nearly half of those with no or mild structural abnormality on imaging had low FE1.

Conclusion Significant association between FE1 and specific imaging findings demonstrates its potential as a marker of exocrine insufficiency and disease severity in chronic pancreatitis. But imaging and FE1 are complementary rather than supplementary.

Keywords

chronic pancreatitis - CT - fecal elastase 1 - MRI - pancreatic exocrine insufficiency

Ethics Approval and Consent to Participate

IRB approval was taken, IRB Min. 14019.


Being a retrospective study, consent was waived.




Publication History

Article published online:
23 June 2022

© 2022. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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