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Drug Res (Stuttg) 2016; 66(12): 660-665
DOI: 10.1055/s-0042-114034
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Ethosomal Curcumin Promoted Wound Healing and Reduced Bacterial Flora in Second Degree Burn in Rat

A. Partoazar
1   Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
,
N. Kianvash
2   Department of Medical Nanotechnology, Faculty of Advanced Sciences & Technology, Pharmaceutical Sciences Branch, Islamic Azad University,Tehran -Iran (IAUPS)
,
M. H. Darvishi
3   Nanobiotecnology Research Center, Baqiyatallah University of Medical Science, Tehran, Iran
,
S. Nasoohi
4   Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Science, Tehran, Iran
,
S. M. Rezayat
5   Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences,Tehran, Iran
,
A. Bahador
6   Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Keshavarz Blvd, 100 Poursina Ave., Tehran, Iran
› Author Affiliations
Further Information

Publication History

received 25 April 2016

accepted 19 July 2016

Publication Date:
14 September 2016 (online)

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Abstract

Background: Curcumin is well known in biomedical investigations with an extensive antimicrobial properties and wound repair effect. However, clinical criteria recommend curcumin should be formulated for topical medication.

Material and method: In this study, we prepared Ethosomal curcumin (Etho-cur) formulation for wound healing and bacterial flora assessments in treated rats which were subjected to second degree burn under a standard procedure.

Results: Applying once daily of Etho-cur (0.2%) topically on rat’s dorsal for 14 days significantly recovered main aspects of wound repair including re-epithelization (P<0.01), neovascularization (P<0.01), collagen synthesis (P<0.001), granulation tissue formation (P<0.001) compared with control. Considerable wound contraction was occurred by Etho-cur treatment sooner than other groups and after 16 days it was completed with a significant (P<0.001) value. Furthermore, ethosomal formulation of curcumin similar to silver sulfadiazine (SSD) cream 1% potentially inhibited (P<0.001) growth of the burn bacterial flora including Pseudomonas aeruginosa as predominant bacteria among experimental isolations during 14 days treatment. Also, antibacterial activity of Etho-cur was estimated approximately 11% more potent than free curcumin in reduction of the burn bacterial flora.

Conclusion: Regarding the results, ethosomal curcumin efficiently fights against wound infection and promotes wound repair in burn injuries in rats.

Key words

burn infection - curcumin - nanoethosom - silver sulfadiazine - wound healing
 

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