CC BY-NC-ND 4.0 · J Neuroanaesth Crit Care 2019; 06(02): 087-095
DOI: 10.1055/s-0039-1689069
Review Article
Indian Society of Neuroanaesthesiology and Critical Care

Clinical Relevance of Blood Glucose Concentration and Hyperglycemia Management in Neurocritical Care Patients

Federico Bilotta
1   Department of Anaesthesia and Critical Care Medicine, Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy
,
Ega Qeva
1   Department of Anaesthesia and Critical Care Medicine, Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy
,
Anna Prete
1   Department of Anaesthesia and Critical Care Medicine, Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy
,
Francesco Pugliese
1   Department of Anaesthesia and Critical Care Medicine, Policlinico Umberto I Hospital, Sapienza University of Rome, Rome, Italy
› Author Affiliations
Funding This review was accomplished with departmental funds.
Further Information

Publication History

Received: 02 February 2019

Accepted after revision: 09 April 2019

Publication Date:
07 June 2019 (online)

Abstract

In patients admitted to a neurocritical care (NCC) unit, management of blood glucose concentration (BGC) is a challenging clinical task. Several studies have shown that episodes of hypo- and hyperglycemia and high BGC variability are associated with poor short- and long-term outcomes. Optimal BGC target-range and BGC management in NCC patients have dramatically evolved in the past decades and new insulin infusion and adequate nutrition protocols are now available. The aim of this narrative review is to report the state-of-the-art on clinical relevance on BGC and hyperglycemia management in NCC patients.

 
  • References

  • 1 Bilotta F, Rosa G. Glucose management in the neurosurgical patient: are we yet any closer?. Curr Opin Anaesthesiol 2010; 23 (05) 539-543
  • 2 Amaral AI. Effects of hypoglycaemia on neuronal metabolism in the adult brain: role of alternative substrates to glucose. J Inherit Metab Dis 2013; 36 (04) 621-634
  • 3 Bilotta F, Giovannini F, Caramia R, Rosa G. Glycemia management in neurocritical care patients: a review. J Neurosurg Anesthesiol 2009; 21 (01) 2-9
  • 4 Jauch-Chara K, Oltmanns KM. Glycemic control after brain injury: boon and bane for the brain. Neuroscience 2014; 283: 202-209
  • 5 Bilotta F, Rosa G. Glycemia management in critical care patients. World J Diabetes 2012; 3 (07) 130-134
  • 6 Walia S, Sutcliffe AJ. The relationship between blood glucose, mean arterial pressure and outcome after severe head injury: an observational study. Injury 2002; 33 (04) 339-344
  • 7 Liu-DeRyke X, Collingridge DS, Orme J, Roller D, Zurasky J, Rhoney DH. Clinical impact of early hyperglycemia during acute phase of traumatic brain injury. Neurocrit Care 2009; 11 (02) 151-157
  • 8 Melo JR, Di Rocco F, Blanot S. et al. Acute hyperglycemia is a reliable outcome predictor in children with severe traumatic brain injury. Acta Neurochir (Wien) 2010; 152 (09) 1559-1565
  • 9 Bhattacharjee S, Layek A, Maitra S, Sen S, Pal S, Gozi NK. Perioperative glycemic status of adult traumatic brain injury patients undergoing craniotomy: a prospective observational study. J Neurosurg Anesthesiol 2014; 26 (04) 313-319
  • 10 Bosarge PL, Shoultz TH, Griffin RL, Kerby JD. Stress-induced hyperglycemia is associated with higher mortality in severe traumatic brain injury. J Trauma Acute Care Surg 2015; 79 (02) 289-294
  • 11 Rau CS, Wu SC, Chen YC. et al. Stress-induced hyperglycemia, but not diabetic hyperglycemia, is associated with higher mortality in patients with isolated moderate and severe traumatic brain injury: analysis of a propensity score-matched population. Int J Environ Res Public Health 2017; 14 (11) E1340
  • 12 Salehpour F, Bazzazi AM, Aghazadeh J. et al. Can serum glucose level in early admission predict outcome in patients with severe head trauma?. World Neurosurg 2016; 87: 132-135
  • 13 Lee SH, Kim BJ, Bae HJ. et al. Effects of glucose level on early and long-term mortality after intracerebral haemorrhage: the Acute Brain Bleeding Analysis Study. Diabetologia 2010; 53 (03) 429-434
  • 14 Wu YT, Li TY, Lu SC. et al. Hyperglycemia as a predictor of poor outcome at discharge in patients with acute spontaneous cerebellar hemorrhage. Cerebellum 2012; 11 (02) 543-548
  • 15 Appelboom G, Piazza MA, Hwang BY. et al. Severity of intraventricular extension correlates with level of admission glucose after intracerebral hemorrhage. Stroke 2011; 42 (07) 1883-1888
  • 16 Sun S, Pan Y, Zhao X. et al. Prognostic value of admission blood glucose in diabetic and non-diabetic patients with intracerebral hemorrhage. Sci Rep 2016; 6: 32342
  • 17 Kim Y, Han MH, Kim CH, Kim JM, Cheong JH, Ryu JI. Increased short-term mortality in patients with spontaneous intracerebral haemorrhage and its association with admission glucose levels and leucocytosis. World Neurosurg 2017; 98: 503-511
  • 18 Elkon B, Cambrin JR, Hirshberg E, Bratton SL. Hyperglycemia: an independent risk factor for poor outcome in children with traumatic brain injury. Pediatr Crit Care Med 2014; 15 (07) 623-631
  • 19 Bian L, Liu L, Wang C. et al. Hyperglycemia within day 14 of aneurysmal subarachnoid hemorrhage predicts 1-year mortality. Clin Neurol Neurosurg 2013; 115 (07) 959-964
  • 20 Koga M, Yamagami H, Okuda S. et al; SAMURAI Study Investigators. Blood glucose levels during the initial 72 h and 3-month functional outcomes in acute intracerebral hemorrhage: the SAMURAI-ICH study. J Neurol Sci 2015; 350 (01) (02) 75-78
  • 21 Sugiura Y, Yamagami H, Sakai N, Yoshimura S. Committee of Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism (RESCUE)-Japan Study Group. Predictors of symptomatic intracranial hemorrhage after endovascular therapy in acute ischemic stroke with large vessel occlusion. J Stroke Cerebrovasc Dis 2017; 26 (04) 766-771
  • 22 Egi M, Bellomo R, Stachowski E. et al. Hypoglycemia and outcome in critically ill patients. Mayo Clin Proc 2010; 85 (03) 217-224
  • 23 Krinsley J, Schultz MJ, Spronk PE. et al. Mild hypoglycemia is strongly associated with increased intensive care unit length of stay. Ann Intensive Care 2011; 1: 49
  • 24 Naidech AM, Levasseur K, Liebling S. et al. Moderate Hypoglycemia is associated with vasospasm, cerebral infarction, and 3-month disability after subarachnoid hemorrhage. Neurocrit Care 2010; 12 (02) 181-187
  • 25 Graffagnino C, Gurram AR, Kolls B, Olson DM. Intensive insulin therapy in the neurocritical care setting is associated with poor clinical outcomes. Neurocrit Care 2010; 13 (03) 307-312
  • 26 Hermanides J, Vriesendorp TM, Bosman RJ, Zandstra DF, Hoekstra JB, Devries JH. Glucose variability is associated with intensive care unit mortality. Crit Care Med 2010; 38 (03) 838-842
  • 27 Matsushima K, Peng M, Velasco C, Schaefer E, Diaz-Arrastia R, Frankel H. Glucose variability negatively impacts long-term functional outcome in patients with traumatic brain injury. J Crit Care 2012; 27 (02) 125-131
  • 28 Okazaki T, Hifumi T, Kawakita K. et al. Blood glucose variability: a strong independent predictor of neurological outcomes in aneurysmal subarachnoid hemorrhage. J Intensive Care Med 2018; 33 (03) 189-195
  • 29 van den Berghe G, Wouters P, Weekers F. et al. Intensive insulin therapy in critically ill patients. N Engl J Med 2001; 345 (19) 1359-1367
  • 30 Finfer S, Chittock DR, Su SY. et al; NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009; 360 (13) 1283-1297
  • 31 Al-Tarifi A, Abou-Shala N, Tamim HM, Rishu AH, Arabi YM. What is the optimal blood glucose target in critically ill patients?. A nested cohort study. Ann Thorac Med 2011; 6 (04) 207-211
  • 32 Okawa M, Kunimoto F, Kanamoto M. et al. Effect of different blood glucose target levels on the incidence of hypoglycemia during insulin therapy in the intensive care unit. J Diabetes 2013; 5 (01) 51-56
  • 33 Siegelaar SE, Hermanides J, Oudemans-van Straaten HM. et al. Mean glucose during ICU admission is related to mortality by a U-shaped curve in surgical and medical patients: a retrospective cohort study. Crit Care 2010; 14 (06) R224
  • 34 Bilotta F, Caramia R, Cernak I. et al. Intensive insulin therapy after severe traumatic brain injury: a randomized clinical trial. Neurocrit Care 2008; 9 (02) 159-166
  • 35 van Iersel FM, Slooter AJ, Vroegop R. et al. Risk factors for hypoglycaemia in neurocritical care patients. Intensive Care Med 2012; 38 (12) 1999-2006
  • 36 Bilotta F, Badenes R, Lolli S, Belda FJ, Einav S, Rosa G. Insulin infusion therapy in critical care patients: regular insulin vs short-acting insulin. A prospective, crossover, randomized, multicenter blind study. J Crit Care 2015; 30 (02) 437.e1-437.e6
  • 37 Desai SV, McClave SA, Rice TW. Nutrition in the ICU: an evidence-based approach. Chest 2014; 145 (05) 1148-1157
  • 38 Tripathy S. Nutrition in the neurocritical care unit. J Neuroanaesth Crit Care 2018; 2: 88-96
  • 39 Gramlich L, Kichian K, Pinilla J, Rodych NJ, Dhaliwal R, Heyland DK. Does enteral nutrition compared to parenteral nutrition result in better outcomes in critically ill adult patients?. A systematic review of the literature. Nutrition 2004; 20 (10) 843-848
  • 40 Härtl R, Gerber LM, Ni Q, Ghajar J. Effect of early nutrition on deaths due to severe traumatic brain injury. J Neurosurg 2008; 109 (01) 50-56
  • 41 Carney N, Totten AM, O'Reilly C. et al. Guidelines for the management of severe traumatic brain injury. Neurosurgery 2017; 80 (01) 6-15