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Thromb Haemost 1979; 42(01): 477
DOI: 10.1055/s-0039-1687602
Supplementary Abstracts
Schattauer GmbH

Effect of Tranylcypromine on Platelet Aggregation Induced by Thrombin, ADP, Adrenaline, Collagen and Arachidonic ACID

C. Busch
1   Department of Pathology, University of Uppsaia, Uppsala, Sweden
,
C. Ljungman
1   Department of Pathology, University of Uppsaia, Uppsala, Sweden
,
L. Birgersson
1   Department of Pathology, University of Uppsaia, Uppsala, Sweden
› Author Affiliations
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Publication Date:
26 April 2019 (online)

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The monoaminooxidase inhibitor tranylcypromine has been suggested to be a selective inhibitor of prostacyclin synthetase with no inhibitory effect on thromboxane A2 formation in platelets. The substance would then be a suitable tool for discrimination between prostacyclin synthesis and release on one hand and other possible thrombocytophobic properties of the endothelial cell particularly its surface on the other. This study, however, shows that tranylcypromine interferes with platelet aggregation induced by thrombin, ADP, adrenaline and collagen whereas that of arachidonic acid is not affected. The results indicate an inhibition at an earlier common pathway of platelet aggregation than the metabolism of arachidonic acid. It is also suggested that the search for a selective inhibitor of prostacyclin synthesis which does not interfere with platelet functions should continue.