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Thromb Haemost 1985; 54(04): 744-745
DOI: 10.1055/s-0038-1660123
Original Article
Schattauer GmbH Stuttgart

The Prevalence of Hereditary Antithrombin-III Deficiency in Patients with a History of Venous Thromboembolism

R Vikydal
The First Department of Medicine, Division of Haematology and Blood Coagulation, University of Vienna, Austria
,
C Korninger
The First Department of Medicine, Division of Haematology and Blood Coagulation, University of Vienna, Austria
,
P A Kyrle
The First Department of Medicine, Division of Haematology and Blood Coagulation, University of Vienna, Austria
,
H Niessner
The First Department of Medicine, Division of Haematology and Blood Coagulation, University of Vienna, Austria
,
I Pabinger
The First Department of Medicine, Division of Haematology and Blood Coagulation, University of Vienna, Austria
,
E Thaler
The First Department of Medicine, Division of Haematology and Blood Coagulation, University of Vienna, Austria
,
K Lechner
The First Department of Medicine, Division of Haematology and Blood Coagulation, University of Vienna, Austria
› Author Affiliations
Further Information

Publication History

Received 24 April 1985

Accepted 27 July 1985

Publication Date:
19 July 2018 (online)

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Summary

Antithrombin-III activity was determined in 752 patients with a history of venous thrombosis and/or pulmonary embolism. 54 patients (7.18%) had an antithrombin-III activity below the normal range. Among these were 13 patients (1.73%) with proven hereditary deficiency. 14 patients were judged to have probable hereditary antithrombin-III deficiency, because they had a positive family history, but antithrombin-III deficiency could not be verified in other members of the family. In the 27 remaining patients (most of them with only slight deficiency) hereditary antithrombin-III deficiency was unlikely. The prevalence of hereditary antithrombin-III deficiency was higher in patients with recurrent venous thrombosis.

Keywords

Hereditary antithrombin-III deficiency - Prevalence - Venous thrombosis
 

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