Use of Factor VIII in the Treatment of Hemophilia^[*]

 

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Summary

This publication describes the results obtained by treatment of haemophiliacs with factor VIII preparations isolated from Cohn fraction I by use of tannic acid, FI-O-Ta.

The authors stress the rapidity of the disappearance of factor VIII after injection. Transfusions are generally well tolerated. One reaction of the pyrogen type has been observed and also a case of activation of the fibrinolytic system.

A second purification method by means of chromatography on DEAE-cellulose is described.

^* Laboratory of Biochemistry. National Cancer Institute. Institute National of Health, Bethesda.

Aided by grants from: The “Consejo Nacional de Investigaciones científicas y técnicas”, Fundación para la Hemofilia and Fundaleu.

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