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Nuklearmedizin 1979; 18(01): 40-45
DOI: 10.1055/s-0037-1620873
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Comparative Chemical, Biological and Clinical Studies of 99mTc-Glucoheptonate and 99mTc-Dimercaptosucci- nate as Used in Renal Scintigraphy

Vergleichende chemische, biologische und klinische Untersuchungen von 99mTc-DMS und 99mTc-GH zur Verwendung für die Nierenszintigraphie
N. Vanlić-Razumenić
1   From the Laboratory of Radioisotopes, Boris Kidric Institute of Nuclear Sciences, Vinča; and the Nuclear Medicine Department, Oncology Institute, Medical Faculty, Novi Sad, Yugoslavia
,
M. Malešević
1   From the Laboratory of Radioisotopes, Boris Kidric Institute of Nuclear Sciences, Vinča; and the Nuclear Medicine Department, Oncology Institute, Medical Faculty, Novi Sad, Yugoslavia
,
Lj. Stefanović
1   From the Laboratory of Radioisotopes, Boris Kidric Institute of Nuclear Sciences, Vinča; and the Nuclear Medicine Department, Oncology Institute, Medical Faculty, Novi Sad, Yugoslavia
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Publication History

Received: 03 August 1978

Publication Date:
05 January 2018 (online)

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The renal radiopharmaceutical preparations 99mTc-DMS and 99mTc-GH were examined chemically, biologically and clinically. Both preparations are of high radiochemical purity. The biodistribution of both preparations was examined in experimental animals at different time intervals, from 15 min to 4 hr; the percentage of incorporation of 99mTc-DMS into kidneys is much higher (29.4% to 52.0%) than that of 99mTc-GH (12.80% to 22.20%). Both preparations accumulate to a greater extent in the renal cortex than in the medulla.

The most suitable time for renal scintigraphy for "mTc-DMS is 90-150 min while for 99mTc-GH it is 60-90 min. It is concluded that 99mTc-DMS is more suitable for static scintigrams on the scanner and 99mTc-GH for dynamic studies with the gamma camera.

Die radiopharmazeutischen Präparate für Nierenuntersuchungen 99mTc-DMS und 99mTc-GH wurden chemisch, biologisch und klinisch geprüft. Beide Präparate zeigen eine hochgradige radiochemische Reinheit. Es wurde die Bioverteilung beider Präparate bei Versuchstieren in verschiedenen Zeitabständen zwischen 15 Min. bis 4 Std. bestimmt; in allen Fällen wurde 99mTc-DMS in einem viel höheren Prozentsatz (29,4 % bis 52 %) als 99mTc-GH (12,8 % bis 22,2 %) in die Nieren eingebaut. Beide Präparate werden in größerem Maße in der Nierenrinde als in der Medulla gespeichert.

Es wurde auch der optimale Zeitpunkt für die Nierenszintigraphie bestimmt: bei 99mTc-DMS betrug er 90-150 Min. und bei 99mTc-GH 60-90 Min. nach der Applikation. Daraus wurde geschlossen, daß 99mTc-DMS eher für statische Szinti- gramme mit dem Scanner und 99mTc-GH eher für dynamische Untersuchungen mit der Gamma-Kamera geeignet sind.

 

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