Synthesis 2018; 50(10): 2087-2093
DOI: 10.1055/s-0037-1609364
paper
© Georg Thieme Verlag Stuttgart · New York

A Convenient and Concise Metal-Free Approach to Functionalized Bicyclic Pyrimidinones from Oxazine-2,6-diones

Ashwini Shirsale
a   Syngenta Biosciences Pvt Ltd, Goa 403110, India   Email: vikas.sikervar@syngenta.com
,
Yogesh Patil
a   Syngenta Biosciences Pvt Ltd, Goa 403110, India   Email: vikas.sikervar@syngenta.com
,
Girish K. Rawal
a   Syngenta Biosciences Pvt Ltd, Goa 403110, India   Email: vikas.sikervar@syngenta.com
,
Jagadish Pabba
a   Syngenta Biosciences Pvt Ltd, Goa 403110, India   Email: vikas.sikervar@syngenta.com
,
Guillaume Berthon
b   Syngenta Crop Protection AG, 4332 Stein AG, Switzerland
,
Ravindra P. Sonawane
a   Syngenta Biosciences Pvt Ltd, Goa 403110, India   Email: vikas.sikervar@syngenta.com
,
Vikas Sikervar*
a   Syngenta Biosciences Pvt Ltd, Goa 403110, India   Email: vikas.sikervar@syngenta.com
› Author Affiliations
We thank Syngenta Research & Technology Centre, Goa for providing the research facility and thank the management for supporting this work.
Further Information

Publication History

Received: 31 January 2018

Accepted after revision: 22 February 2018

Publication Date:
20 March 2018 (online)


Abstract

The synthesis of previously unreported pyrazolo-pyrimidinones and isoxazolo-pyrimidinones are achieved via metal-free coupling of oxazine-2,6-diones with pyrazolidinone and isoxazolidinone, respectively. The synthesis provides easy access to a variety of novel 2-dimensional building blocks that can be derivatized to generate a range of drug- and agro-like molecules.

Supporting Information

 
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