Gesundheitswesen 2017; 79(08/09): 656-804
DOI: 10.1055/s-0037-1605765
Vorträge
Georg Thieme Verlag KG Stuttgart · New York

Association of sCD14 in human breast milk with child atopic dermatitis: Results of the Ulm Birth Cohort Study and the Ulm SPATZ Health Study

CA Logan
1   Universität Ulm, Institut für Epidemiologie und Medizinische Biometrie, Ulm
,
J Weiss
2   Universitätsklinikum Ulm, Universitätsklinik für Dermatologie und Allergologie, Ulm
,
W Koenig
3   Universitätsklinikum Ulm, Abteilung Innere Medizin II – Kardiologie, Ulm
,
V Walter
4   Deutsches Krebsforschungszentrum, Klinische Epidemiologie und Alternsforschung, Heidelberg
,
H Brenner
4   Deutsches Krebsforschungszentrum, Klinische Epidemiologie und Alternsforschung, Heidelberg
,
D Rothenbacher
1   Universität Ulm, Institut für Epidemiologie und Medizinische Biometrie, Ulm
,
J Genuneit
1   Universität Ulm, Institut für Epidemiologie und Medizinische Biometrie, Ulm
› Author Affiliations
Further Information

Publication History

Publication Date:
01 September 2017 (online)

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Background:

Soluble CD14 (sCD14) is one of many factors present in human breast milk which may influence programming of the immune response in the breastfed child. Though previous studies have mostly found little association between sCD14 concentration in breast milk and atopic outcomes, these studies have lacked sufficient sample size while recent evidence continues to support a role of sCD14 in immune-related disease. We aimed to clarify whether an association exists between sCD14 concentration in human breast milk and atopic dermatitis (AD) diagnosis by age 3 years within the context of two large birth cohorts.

Methods:

Data were obtained from the Ulm Birth Cohort Study (UBCS) and the Ulm SPATZ Health Study, methodologically similar birth cohort studies, each consisting of approximately 1,000 newborns and their mothers recruited from the general population shortly after delivery in the University Medical Centre Ulm, Southern Germany, respectively from 11/2000 – 11/2001 and 04/2012 – 05/2013. sCD14 concentrations were measured by different ELISAs (UBCS: IBL, SPATZ: R&D) in breast milk samples collected at 6 weeks post-delivery in both studies and additionally at 6 months and 1 year in SPATZ only. AD diagnosis was assessed by parent and pediatrician report at 1, 2, and 3 years of age.

Results:

sCD14 concentrations and complete AD data were available for 687 and 581 UBCS and SPATZ children, respectively. Demographic and lifestyle factors were inconsistently associated with sCD14 concentrations across cohorts with the exception of maternal education with higher levels in lower educated mothers (p < 0.05). Testing different AD case definitions, crude and adjusted models showed no association of sCD14 concentrations at any collection time with AD in either study.

Conclusions:

Our results from two large cohorts using differing exposure but same outcome and confounder measurement do not support an association of sCD14 in breast milk with AD among breastfed children.