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DOI: 10.1055/s-0035-1565423
Five new anti-inflammatory active flavonoids from the aerial part of Lindera akoensis
Lindera akoensis (Lauraceae) is an endemic evergreen tree that grows in broad-leaved forests in lowlands throughout Taiwan. Aporphines, alkaloids, sesquiterpenoids, butanolides, furanoids, chalconoids, and phenolic compounds were widely distributed in the plants of the genus Lindera. Some isolates exhibit biological activies, including anti-mycobacterial, anti-inflammatory, anti-human lung cancer (SBC-3), osteoclast differentiation inhibitory, human slowing down of the pregession of diabetic nephropathy in mice, anti-nociceptive, and LDL anti-oxidation effect et al.. In this study, we have isolated five new flavonoids, 4'-O-methyl-2”-Z-p-coumaroylafzelin (1), 4'-O-methyl-2”-E-p-coumaroylafzelin (2), 4'-O-methyl-2”,4”-di-E-p-coumaroylafzelin (3), 4'-O-methyl-2”,4”-di-E-p-coumaroyltamarixetin (4), kaemferol-3-O-α-L-4”,6”-di-E-p-coumaroylglucoside (5). The structures of these new compounds were determined by the analysis their spectroscopic date. The compounds 1, 2, 3, 4 and 5 exhibited anti-inflammatory activity decrease the LPS-stimulated product of nitrite in RAW 264.7 cells with IC50 values of 14.9, 11.3, 6.9, 25.5 and 15.6 µg/ml, respectively. (Indomethacin was used as positive control with IC50 value of 182.9 µM)
