Synlett 2016; 27(17): 2497-2499
DOI: 10.1055/s-0035-1562776
letter
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Ieodomycin D

Jørn Eivind Tungen
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068, Blindern, N-0316 Oslo, Norway   Email: anders.vik@farmasi.uio.no
,
Marius Aursnes
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068, Blindern, N-0316 Oslo, Norway   Email: anders.vik@farmasi.uio.no
,
Anders Vik*
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068, Blindern, N-0316 Oslo, Norway   Email: anders.vik@farmasi.uio.no
› Author Affiliations
Further Information

Publication History

Received: 15 April 2016

Accepted after revision: 17 June 2016

Publication Date:
14 July 2016 (online)


Abstract

A synthesis of the marine natural product ieodomycin D has been achieved in seven steps and 16% overall yield from commercially available pyridinium-1-sulfonate. The key synthetic step was a B-alkyl Suzuki–Miyaura cross-coupling reaction. The enantiomer of ieodomycin D was also prepared using the same synthetic strategy.

Supporting Information

 
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