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DOI: 10.1055/s-0033-1336210
Combined Modality Treatment of Sinonasal SCC
Squamous cell carcinoma (SCC) remains the most common sinonasal malignancy, although it is often difficult to say exactly where the tumor arose, the maxillary sinus, ethmoids, and nasal cavity are most commonly affected.
We present 30 cases of primary sinonasal SCC treated at Charing Cross Hospital London (UK) consecutively between 2002 and 2011. Eighteen patients were male, and 12 were female, with an age range of 16 to 90 years (mean, 58 years). Treatment was combined modality with a combination of primary surgery and postoperative radiotherapy or primary radiotherapy (± chemotherapy) followed by surgery. The surgical approach was usually craniofacial resection or via mid-facial degloving. Results were analyzed in terms of local control, locoregional control, disease-specific survival, and overall survival.
We now feel that best results may be obtained with initial chemoradiotherapy, followed by planned aggressive surgery, with resection of all areas involved at presentation (± orbital exenteration and neurosurgical resection). Reconstruction may involve free tissue transfer, although excellent results can often be obtained with osseointegrated prosthetics.