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DOI: 10.1055/s-0032-1310487
Role of three childhood acute lymphoblastic leukemia-associated SNPs in a pediatric non-Hodgkin lymphoma cohort
Aim: Investigation of candidate SNPs previously described to influence the risk of developing childhood acute lymphoblastic leukemia, in pediatric non-Hodgkin lymphoma (NHL).
Methods: Genotyping of SNPs rs4132601 (IKZF1), rs7089424 (ARID5B) and rs2239633 (CEBPE) in 498 German pediatric NHL cases treated on protocol NHL-BFM 95 and 1832 healthy individuals from the PopGen biobank.
Results: No evidence of significant differences regarding the genotype distribution of the three SNPs was found between the entire NHL population as well as specific subgroups and healthy controls.
Conclusion: The analyzed SNPs in IKZF1, ARID5B and CEBPE have no significant influence on developing pediatric NHL.