Klin Padiatr 2012; 224 - A20
DOI: 10.1055/s-0032-1310487

Role of three childhood acute lymphoblastic leukemia-associated SNPs in a pediatric non-Hodgkin lymphoma cohort

T Bartram 1, K Seidemann 2, B Burkhardt 3, W Wössmann 4, M Zimmermann 2, E Ellinghaus 5, A Franke 5, S Schreiber 5, M Schrappe 1, A Reiter 4, M Stanulla 1
  • 1Department of Paediatrics, University Hospital Schleswig-Holstein, Kiel
  • 2Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover
  • 3Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster
  • 4Department of Paediatric Haematology and Oncology, Justus Liebig University, Gießen
  • 5Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany

Aim: Investigation of candidate SNPs previously described to influence the risk of developing childhood acute lymphoblastic leukemia, in pediatric non-Hodgkin lymphoma (NHL).

Methods: Genotyping of SNPs rs4132601 (IKZF1), rs7089424 (ARID5B) and rs2239633 (CEBPE) in 498 German pediatric NHL cases treated on protocol NHL-BFM 95 and 1832 healthy individuals from the PopGen biobank.

Results: No evidence of significant differences regarding the genotype distribution of the three SNPs was found between the entire NHL population as well as specific subgroups and healthy controls.

Conclusion: The analyzed SNPs in IKZF1, ARID5B and CEBPE have no significant influence on developing pediatric NHL.