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Endoscopy 2012; 44(06): 618-621
DOI: 10.1055/s-0032-1306774
Innovation Forum
© Georg Thieme Verlag KG Stuttgart · New York

Lymph node characterization in vivo using endoscopic ultrasound spectrum analysis with electronic array echo endoscopes

R. E. Kumon
1   Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
2   Department of Physics, Kettering University, Flint, Michigan, USA
,
A. Repaka
3   Division of Gastroenterology, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, Ohio, USA
4   University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA
,
M. Atkinson
3   Division of Gastroenterology, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, Ohio, USA
,
A. L. Faulx
3   Division of Gastroenterology, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, Ohio, USA
,
R. C. K. Wong
3   Division of Gastroenterology, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, Ohio, USA
,
G. A. Isenberg
3   Division of Gastroenterology, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, Ohio, USA
,
Y.-S. Hsiao
1   Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
,
M. S. R. Gudur
1   Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
,
C. X. Deng
1   Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
,
A. Chak
3   Division of Gastroenterology, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, Ohio, USA
› Author Affiliations
Further Information

Publication History

submitted 01 July 2011

accepted after revision 10 January 2012

Publication Date:
25 May 2012 (online)

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Our purpose was to demonstrate the use of radiofrequency spectral analysis to distinguish between benign and malignant lymph nodes with data obtained using electronic array echo endoscopes, as we have done previously using mechanical echo endoscopes. In a prospective study, images were obtained from eight patients with benign-appearing lymph nodes and 11 with malignant lymph nodes, as verified by fine-needle aspiration. Midband fit, slope, intercept, correlation coefficient, and root-mean-square (RMS) deviation from a linear regression of the calibrated power spectra were determined and compared between the groups. Significant differences were observable for mean midband fit, intercept, and RMS deviation (t test P < 0.05). For benign (n = 16) vs. malignant (n = 12) lymph nodes, midband fit and RMS deviation provided classification with 89 % accuracy and area under receiver operating characteristic (ROC) curve of 0.95 based on linear discriminant analysis. We concluded that the mean spectral parameters of the backscattered signals from electronic array echo endoscopy can provide a noninvasive method to quantitatively discriminate between benign and malignant lymph nodes.

 

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