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DOI: 10.1055/s-0031-1279450
Integrated CT-perfusion in patients with prostate cancer: Initial correlation of perfusion parameters with PSA and Gleason Score
Ziele: 1. To integrate CT-perfusion of the prostate into an abdominal CT,
2. to correlate PSA and Gleason score with perfusion parameters. Methode: Nineteen male patients (mean age: 68 (53–81) years) with prostate cancer were prospectively included. Patients were referred for routine abdominal staging CT.
A split-injection protocol, including a 50-second prostate-perfusion scan was performed. First, 40ml contrast media were injected (Ultravist 370, flow: 4ml/s), after a 10 second delay, perfusion imaging using shuttle mode was started (1sec rotation time, 0.5cm slice thickness, 7cm cranio-caudal FOV) Another 60ml of contrast media were injected (4ml/s) to ensure full diagnostic portal venous imaging. CT-perfusion parameters (blood flow (BF), blood volume (BV) and mean transit time (MTT)) were calculated and correlated with PSA levels and Gleason scores. Ergebnis: The mean BF, BV and MTT of the prostate was 52.9ml/100g, 5.1ml/100g tissue and 6.7 seconds. The mean BF, BV and MTT in healthy tissue was 16.5ml/100g, 1.3ml/100g tissue and 5.9 seconds. Mean PSA level was 42.3 (range 5–472 mcg/l), mean Gleason score was 7 (range 6–10). There was a weak correlation between BV and PSA-levels (coefficient=0.3), all other perfusion parameters, PSA-level and Gleason score showed only very low or no correlation. Schlussfolgerung: Integrated CT-perfusion in a routine abdominal CT for prostate cancer evaluation is feasible. CT-perfusion might add significant information non-invasively about prostate cancer. However, only weak correlations could be demonstrated between perfusion parameters and clinical parameters.
Keywords: Prostate Cancer, Perfusion CT, PSA, Gleason Score
Korrespondierender Autor: Huellner MW
Kantonsspital Luzern, Institut für Radiologie und Nuklearmedizin, Spitalstrasse 1, 6004, Luzern
E-Mail: martin.huellner@ksl.ch