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Synfacts 2010(8): 0940-0940  
DOI: 10.1055/s-0030-1257754
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

A P,N-Ligand for the Palladium-Catalyzed Arylation of Ammonia

Contributor(s): Paul Knochel, Andreas J. Wagner
R. J. Lundgren, B. D. Peters, P. G. Alsabeh, M. Stradiotto*
Dalhousie University, Halifax, Canada
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Publication History

Publication Date:
22 July 2010 (online)

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Significance

Ammonia is used as an abundant and inexpensive nitrogen source for the performance of a palladium-catalyzed amination of aromatic chlorides and tosylates. The reaction conditions tolerate amino groups already present in the starting aryl chlorides or tosylates. The amination proceeds chemoselectively with ammonia yielding a variety of substituted anilines in high yields.