The rs1800629 Polymorphism in the TNF Gene Interacts with Physical Activity on the Changes in C-reactive Protein Levels in the Finnish Diabetes Prevention Study

 

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Abstract

Physical activity exerts anti-inflammatory effects, but genetic variation may modify its influence. In particular, the rs1800629 single-nucleotide polymorphism (SNP) in the tumor necrosis factor (TNF) gene and the rs1800795 SNP in the interleukin-6 (IL6) gene have been found to modify the effect of exercise training on circulating levels of C-reactive protein (CRP) and IL-6, respectively. We assessed whether rs1800629 and rs1800795 modified the effect of moderate-to-vigorous physical activity on changes in serum levels of high-sensitivity CRP and IL-6 in the Finnish Diabetes Prevention Study (DPS). Genotype and 1-year data on changes in physical activity, serum CRP and IL-6 were available for 390 overweight subjects with impaired glucose tolerance. The rs1800629 SNP in TNF interacted with the 1-year change in moderate-to-vigorous physical activity on changes in CRP among those who had high (≥3 mg/L) baseline CRP levels (P=0.034 for interaction). Carriers of the GG genotype showed a greater decrease in CRP with increasing physical activity than the individuals with the A allele. No interaction between the rs1800795 SNP in IL6 and changes in moderate-to-vigorous physical activity on the 1-year change in serum IL–6 was found. In conclusion, the rs1800629 SNP in the TNF gene may modify the effect of moderate-to-vigorous physical activity on serum levels of CRP.

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Correspondence

T. O. Kilpeläinen

MRC Epidemiology Unit

Institute of Metabolic Science

Box 285

Addenbrooke's Hospital

Hills Road

CB2 0QQ Cambridge

United Kingdom

Phone: +44/01223/7691 64

Fax: +44/01223/3303 16

Email: tuomas.kilpelainen@mrc-epid.cam.ac.uk