Subscribe to RSS
DOI: 10.1055/s-0029-1247002
Creation of an acute tricuspid regurgitation and tricuspid annular dilatation using video-assisted cardioscopy cardioport imaging in an animal model
Objectives: Experimental models of tricuspid regurgitation (TR) are necessary to study the feasibility of surgical placement of annuloplasty ring. Our aim is to develop an appropriate simple and reproducible experimental model for creation of tricuspid regurgitation.
Methods: Tricuspid regurgitation was successfully created through multiple small 3–5mm incisions using a cardioport inserted via the right atrium in five Yorkshire pigs. Preoperative annular dimensions were 21±0.4mm, anatomy and function of tricuspid valve were all evaluated by 2D and 3D echocardiogram. Presence and severity of regurgitation, diameter of annulus, and significant increase in heart rate and right atrial pressures after annular incisions were documented.
Results: Acute onset of tricuspid regurgitation was well tolerated. There was neither morbidity nor mortality. To monitor tricuspid annular dilatation and progression of TR, follow-up echocardiography and color Doppler examination at 2 and 8 weeks postoperatively was performed. Annular diameter increased markedly (31.4±0.8 and 36±0.3mm, respectively) and regurgitation progressed from mild (2o) to severe (3o).
Conclusions: This novel porcine model is relatively simple and reproducible surgical technique for creation of acute tricuspid regurgitation and subsequent annular dilatation.
Fig. Cardioport