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Exp Clin Endocrinol Diabetes 1992; 99(2): 68-70
DOI: 10.1055/s-0029-1211136
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© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Dehydroepiandrosterone (DHEA) Levels in Patients with Prostatic Cancer, Heart Diseases and under Surgery Stress

F. Stahl, D. Schnorr, C. Pilz, G. Dörner
  • Institute of Experimental Endocrinology, Department of Urology, Humboldt University Medical School (Charité), Berlin, and First Surgical Clinic, Berlin-Buch (Germany)
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Publication History

1991

Publication Date:
15 July 2009 (online)

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Summary

DHEA levels in patients with prostatic cancer were significantly lower, but total and free testosterone (T) significanctly higher as those in an age-matched control group. Therefore, the calculated quotients DHEA/free T and DHEA/T were especially different between both groups. DHEA and DHEAS levels in patients with heart dieseases were also significantly lower but cortisol (F) levels were significantly higher as those in a control group. The quotients DHEA/F and DHEAS/F were also of greater significance between both groups than the hormone values alone. The response of DHEA and F levels in patients undergoing surgery showed an increase of both steroids under surgery. On the second postoperative day, however, F levels were still significantly higher but DHEA levels were significantly lower as the initial values. The differences between the initial values and those on the second postoperative day of F and DHEA showed a significant correlation, i.e. the higher the elevation of F levels above the initial values the greater was the diminution of DHEA levels below the initial values.

Key words

Dehydroepiandrosterone - Prostatic cancer - Heart disease - Surgery stress

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