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Exp Clin Endocrinol Diabetes 1989; 94(4/05): 171-176
DOI: 10.1055/s-0029-1210894
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Human Early Pregnancy Factor and Early Pregnancy Associated Protein before and after Therapeutic Abortion in Comparison with ß-hCG, Estradiol, Progesterone and 17-Hydroxyprogesterone*)

V. Hübel, W. Straube, Margaretha Loh, W. Wodrig, A. Weber, F. Klima
  • Clinic of Gynaecology and Obstetrics (Head: Prof. Dr. sc. med. G. Göretzlehner) and Clinic of Radiology (Head: Prof. Dr. sc. med. W. Schmidt) Ernst Moritz Arndt University of Greifswald, Greifswald, GDR Vertebrate Research Centre (Head: Prof. Dr. sc. Dr. h. c. H. Dathe) of the Academy of Science of the GDR, Berlin, GDR
*) To Prof. Dr. sc. med. G. Dörner on occasion of his 60th birthday.
Further Information

Publication History

1988

Publication Date:
16 July 2009 (online)

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Summary

Serum activities and concentrations, respectively, of early pregnancy factor (EPF), early pregnancy associated protein (EPAP), β-hCG, estradiol, progesterone and 17-hydroxyprogeste-rone were estimated in 20 healthy primigravidae within the tenth to twelfth completed gestational week before and after therapeutic abortion. EPF, β-hCG and estradiol markedly decreased after termination of pregnancy, whereas progesterone and 17-hydroxyprogesterone concentrations moderately fell.

EPAP showed no significant alterations in a 24 hours period. Because of its possible role as immunosuppressive substance and its short half-life EPF may be a promising immunobiomarker for disturbances in early pregnancy.

Key words

Early pregnancy factor - Early pregnancy associated protein - Estradiol - Chorionic gonadotropin - Progesterone - Therapeutic abortion

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