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Exp Clin Endocrinol Diabetes 1985; 86(5): 233-236
DOI: 10.1055/s-0029-1210491
Short Communication

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Influence of Microinjection of Insulin into Amygdala on Acetate Metabolism in Liver Slices of Rabbit

K. Seto, H. Saito, N. Edashige1 , T. Kawakami, K. Yoshimatsu, C. Horiuchi, M. Kawakami †2
  • First Department of Physiology (Chairman: Prof. Dr. K. Seto), Kochi Medical Sohool, Nankoku, Yokohama City University School of Medicine, Yokohama/Japan
  • 1Department of Medical Technology (Chairman: Prof. Dr. S. Sato), Kochi Gakuen college, Kochi, Yokohama City University School of Medicine, Yokohama/Japan
  • 2Second Department of Physiology (Former Chairman: Prof. Dr. M. Kawakami †), Yokohama City University School of Medicine, Yokohama/Japan
Further Information

Publication History

1984

Publication Date:
16 July 2009 (online)

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Summary

Insulin was injected directly into the medial amygdala (AMYG) of rabbits, and changes in hepatic acetate metabolism were studied. The injection of 50 µU insulin into the AMYG decreased the rates of 14C transfer from 14C-l-acetate into CO2 and cholesterol ester, and inoreased those into free cholesterol and phospholipids. But after insulin injection into parietal cortex of intact rabbits and into the AMYG of rabbits with lesions of stria terminalis (ST), hepatic acetate metabolism did not differ from that of the control rabbits, which received saline injection into the same brain regions. These observations support the hypothesis that the AMYG is a part of insulin-sensitive brain regulator system in the hepatic acetate metabolism.

Key words

Insulin - Amygdala - Acetate metabolism

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