Effect of Flutamide, a Nonsteroidal Antiandrogen on Functional Maturation of the Epididymis of Rat

J. D. Dhar; S. K. Srivastava; B. S. Setty

doi:10.1055/s-0029-1210269

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Exp Clin Endocrinol Diabetes 1983; 82(5): 140-144
DOI: 10.1055/s-0029-1210269

Original

Effect of Flutamide, a Nonsteroidal Antiandrogen on Functional Maturation of the Epididymis of Rat

J. D. Dhar, S. K. Srivastava, B. S. Setty

Division of Endocrinology, Central Drug Research Institute, Lucknow/India

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Publication History

1982

Publication Date:
17 July 2009 (online)

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Summary

The effect of flutamide, a non-steroidal antiandrogen on the growth and secretory function of the epididymis of rat during transition from prepubertal age (35 days old) to puberty (50 days old) was investigated. The results showed that the antiandrogen interfered with the growth of all the genital organs accompanied by a marked reduction in the secretory function of the epididymis as revealed by lowered levels of sialic acid and glycerylphosphorylcholine. These findings are discussed in relation to our previous observations in adult rats.

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