Three New Phenolic Glycosides and a New Triterpenoid from the Stems of Scolopia chinensis

 

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Abstract

Three new phenolic glycosides, scolochinenosides C–E (1–3), and a new triterpenoid, scolopianate A (4), were isolated from the stems of Scolopia chinensis, along with 15 known compounds. The structures of the new compounds were elucidated by means of extensive spectroscopic and chemical methods. Compound 3 contains a novel highly oxygenated lactone bridge ring attached at the aglycone. Six lanostane triterpenoids (10–15) were discovered for the first time in a species other than Ganoderma lucidum (Polyporaceae). In addition, the phenolic glycosides were evaluated for their inhibitory activity against snake venom phosphodiesterase I.

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Prof. Peng-Fei Tu

State Key Laboratory of Natural and Biomimetic Drugs
School of Pharmaceutical Sciences
Peking University Health Science Center

38 Xueyuan Road

Haidian District

100191 Beijing

People's Republic of China

Phone: + 86 10 82 80 27 50

Fax: + 86 10 82 80 27 50

Email: pengfeitu@vip.163.com

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