Acid-Mediated Synthesis of 3-N,N-Dialkyl-amino-1,2,4-Triazoles

D. V. Batchelor; D. M. Beal; T. B. Brown; D. Ellis; D. W. Gordon; P. S. Johnson; H. J. Mason; M. J. Ralph; T. J. Underwood; S. Wheeler

doi:10.1055/s-0028-1087330

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Synfacts 2008(12): 1263-1263
DOI: 10.1055/s-0028-1087330

Synthesis of Heterocycles

Acid-Mediated Synthesis of 3-N,N-Dialkyl-amino-1,2,4-Triazoles

Contributor(s): Victor Snieckus, Johnathan Board
D. V. Batchelor, D. M. Beal, T. B. Brown, D. Ellis, D. W. Gordon, P. S. Johnson, H. J. Mason, M. J. Ralph, T. J. Underwood, S. Wheeler*
Pfizer Global Research and Development, Sandwich, UK

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Publication History

Publication Date:
20 November 2008 (online)

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Significance

Reported are acid-mediated conditions for the formation of highly substituted 1,2,4-triazoles from the reaction of S-methylisothioureas with acyl hydrazides. The starting thioureas were synthesized in excellent yield through sequential reaction of di-2-pyridyl-thiocarbonate with primary amines.