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Synlett 2023; 34(16): 1839-1844
DOI: 10.1055/a-2071-4411
synpacts

Vibrational Circular Dichroism Studies on Axially Chiral Carbodiimides and Allenes

Tohru Taniguchi  ∗
This work was supported by KAKENHI (grant no. JP18H02093 and JP18KK0394) and the TOBE MAKI scholarship foundation (19-JA-013).
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Abstract

The axial chirality of molecules with two consecutive double bonds (X=Y=Z) has not been well studied because of a lack of analytical methods and because of difficulties in their preparation in enantiomerically pure forms. This Synpacts article describes the use of vibrational circular dichroism spectroscopy to study the stereochemistry of carbodiimides and allenes. A strategy to obtain carbodiimides with one-handed chirality by using conformationally restrained frameworks is also discussed.

1 Introduction

2 Carbodiimides with Partially Biased Axial Chirality and One-Handed Axial Chirality

3 Axially Chiral Allenes

4 Conclusions

Key words

vibrational circular dichroism - carbodiimides - allenes - axial chirality - structural analysis


Publication History

Received: 28 February 2023

Accepted after revision: 11 April 2023

Accepted Manuscript online:
11 April 2023

Article published online:
10 May 2023

© 2023. Thieme. All rights reserved

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