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CC BY-NC-ND 4.0 · Endosc Int Open 2022; 10(05): E703-E706
DOI: 10.1055/a-1788-9888
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Factors contributing to changes in viscosity and flow rate of a dedicated gel for gel immersion endoscopy

Yuji Hiraki
1   Naruto Research Institute, Research and Development Center, Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan
,
Atsushi Ohata
1   Naruto Research Institute, Research and Development Center, Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan
,
Tomonori Yano
2   Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan
,
Yoshimasa Miura
2   Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan
,
Alan Kawarai Lefor
3   Department of Surgery, Jichi Medical University, Tochigi, Japan
,
Hironori Yamamoto
2   Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan
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Abstract

Background and study aims Gel immersion endoscopy is a novel technique for securing the visual field during endoscopy. Clinical application of a dedicated gel for this technique with an appropriate viscosity to prevent mixing with blood and its efficacy was reported. The aim of this study was to evaluate changes in gel viscosity and flow rate under different conditions.

Methods The viscosity of the gel after injection and flow rate were measured under various conditions changing the injection route and method. Gel viscosity was measured at 25, 10, and 4 °C.

Results A decrease in gel viscosity was found when the gel was injected via the water jet channel compared to the accessory channel. The flow rate and decrease in viscosity of the gel injected via the water jet channel were 220 mL/min and 63.2 %, while when injected via the accessory channel with a clip device inserted were 560 mL/min and 35.8 %. When the gel was kept at a low temperature, the viscosity increased.

Conclusions Gel injection via the accessory channel should be the first choice for efficient use considering the viscosity and flow rate.



Publication History

Received: 13 September 2021

Accepted after revision: 06 December 2021

Article published online:
13 May 2022

© 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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Letter to this article:

Gel stored at low temperature maintains high viscosity even when injected via the water jet channelEndosc Int Open 2022; 10(09): E1172-E1173
DOI: 10.1055/a-1906-3713

 

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