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Int J Sports Med 2010; 31(4): 221-224
DOI: 10.1055/s-0030-1247529
Rapid Communication

© Georg Thieme Verlag KG Stuttgart · New York

ACE and ACTN3 Genes and Muscle Phenotypes in Nonagenarians

N. Bustamante-Ara1 , C. Santiago1 , Z. Verde1 , T. Yvert1 , F. Gómez-Gallego1 , G. Rodríguez-Romo2 , P. González-Gil3 , J. A. Serra-Rexach4 , J. R. Ruiz5 , A. Lucia1
  • 1Universidad Europea de Madrid, Biomedicine, Madrid, Spain
  • 2Universidad Politécnica, INEF, Madrid, Spain
  • 3Residencia Los Nogales-Pacífico, Medical Department, Madrid, Spain
  • 4Hospital Gregorio Marañón, Gerontology, Madrid, Spain
  • 5Karolinska Institutet, Dpt. Biosciences and Nutrition, Unit for Preventive Nutrition, Huddinge, Sweden
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Publication History

accepted after revision December 20, 2009

Publication Date:
10 February 2010 (online)

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Abstract

We studied the association of ACE and ACTN3 polymorphisms with skeletal muscle phenotypes (i. e. upper and lower body muscular strength and functional tests) in Spanish nonagenarian subjects [n=41, 33 women, 8 men, age: 90–97 years]. Mean values of the study phenotypes were not significantly different (all P>0.05) between ACE and ACTN3 genotypes. The analyses of the combined effects between genotypes (ACE DD & ACTN3 RR/RX vs. ACE II/ID & ACTN3 XX) did not yield any significant difference. Our data suggest that, in the elderly, the influence of genetic factors on muscle phenotype traits is not reducible to a few single polymorphisms, including ACE and ACTN3 variants.

Key words

nonagenarians - muscular strength - ACE genotype - ACTN3 genotype

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Correspondence

Prof. Alejandro Lucia

Universidad Europea De Madrid Physiology

Villaviciosa de Odón

28670 Madrid

Spain

Phone: +34/916647800

Fax: +34/916168265

Email: alejandro.lucia@uem.es

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