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Synlett 1997; 1997(1): 119-120
DOI: 10.1055/s-1997-712
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Asymmetric Michael Reaction of α-Cyano Esters Catalyzed by Chiral Rh(I) Complexes with a New Optically Active Biphosphine Ligand

Kohji Inagaki, Kyoko Nozaki* , Hidemasa Takaya1
  • *Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Sakyo-ku, Kyoto 606-01, Japan
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Publication Date:
22 March 2004 (online)

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Asymmetric addition of 2-cyanoproprionates to methyl vinyl ketone in the presence of 1 mol% of chiral Rh(I) catalysts containing a novel chiral bisphosphine ligand ((R)-7,7'-bis(diphenylphosphinomethyl)-2,2'-dimethoxy-1,1'-binaphthyl) gave optically active Michael adducts in good yields with enantiomeric excesses up to 73% ee.

asymmetric Michael reaction - rhodium catalyst - chiral bisphosphine - α-cyano ester

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