The effects of a diet rich in docosahexaenoic acid on organ and vascular fatty acid composition in spontaneously hypertensive rats

doi:10.1054/plef.1999.0102

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)

Volume 61, Issue 5, November 1999, Pages 289-295

https://doi.org/10.1054/plef.1999.0102 Get rights and content

Abstract

Previous research has shown that dietary docosahexaenoic acid (DHA) attenuates the development of high blood pressure in young spontaneously hypertensive rats (SHR). The purpose of this study was to investigate the effects of dietary DHA on organ and vascular fatty acid composition in SHR. Given the important structural and functional role of fatty acids in cell membranes, alterations in fatty acid composition may contribute to the antihypertensive effect of DHA. SHR were fed a purified diet containing either a corn/soybean oil mixture (CSO, control) or a DHA-enriched oil for 6 weeks. The DHA diet markedly increased the levels of DHA in the aorta, renal artery, plasma, liver, heart, kidney, and lung by 5-, 15-, 7-, 6-, 3.8-, 3.5-, and 8.8-fold (P⪡0.001), respectively. The levels of eicosapentaenoic acid were also increased while there was a concomitant reduction in arachidonic and adrenic acids. Therefore, dietary DHA increases the incorporation of ω-3 polyunsaturated fatty acids in specific organs and vascular tissue in SHR at the expense of ω-6 polyunsaturated fatty acids.

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Regular ArticleThe effects of a diet rich in docosahexaenoic acid on organ and vascular fatty acid composition in spontaneously hypertensive rats

Abstract

Eur J Pharmacol

Prog Lipid Res

Prostaglandins Leukot Essent Fatty Acids

Prostaglandins leuko Essent Fatty Acids

Asia Pacific Heart J

Prostaglandins

Prostaglandins Leukot Essent Fatty Acids

J Lipid Res

Biochim Biophys Acta

J Nutr

Prot Med

Cardiovascular effects of n-3 fatty acids

New Engl J Med

The antihypertensive effects of fish oil: a controlled study of polyunsaturated fatty acid supplements in essential hypertension

New Engl J Med

Effect of eicosapentaenoic acid and docosahexaenoic acids on blood pressure in hypertension

New Engl J Med

Does fish oil lower blood pressure? A meta-analysis of controlled trials

Circulation

Does supplementation of diet with fish oil reduce blood pressure

Arch Int Med

Effects of dietary sodium and fish oil on blood pressure development in stroke-prone spontaneously hypertensive rats

J Hypertens

Dietary fish oil administration retards blood pressure development and influences vascular properties in the spontaneously hypertensive rat, but not in the stroke-prone spontaneously hypertensive rat

Blood Pressure

Vasorelaxant properties of n-3 polyunsaturated fatty acids in aortas from spontaneously hypertensive and normotensive rats

J Cardiovasc Risk

Calcium-mediated mechanisms of eicosapentaenoic acid-induced relaxation in hypertensive rat aorta

Am J Hypertens

Influence of aging on the relaxant responses to ω-3 fatty acids in Fischer 344 rat aorta

Gerontology

Docosahexaenoic acid is an antihypertensive nutrient which affects aldosterone production in SHR

Proc Soc Exp Biol Med

Regular Article
The effects of a diet rich in docosahexaenoic acid on organ and vascular fatty acid composition in spontaneously hypertensive rats