Regular ArticleBOC-CCK-4, CCKBreceptor agonist, antagonizes anxiolytic-like action of morphine in elevated plus-maze☆
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Revisiting the role of anxiety in the initial acquisition of two-way active avoidance: pharmacological, behavioural and neuroanatomical convergence
2020, Neuroscience and Biobehavioral ReviewsCitation Excerpt :A variety of different susbtances acting on systems other than the GABA-A/BZ o 5-HT have also been reported to have anxiolytic-like effects in typical rodent tests of anxiety as well as a facilitating action on TWAA acquisition. Among these, morphine, an opiate receptor agonist with well-established anxiolytic-like effects in rodents (e.g. Craft et al., 1988; Davis, 1986; Kõks et al., 1999; Motta and Brandão, 1993), was shown to improve TWAA acquisition, especially in relatively “poor performer” batches of rats (Davis and Smith, 1975; Satinder, 1976) as well as in mice in a more recent study (Aguilar et al., 2004a) (Table 1), although in the latter study morphine effects have been attributed to a general increase of motor activity that was observed during the adaptation period (to the shuttle box) preceding training (but see further discussion on this issue in section 6.3). Thus further research is warranted to determine whether morphine or other opiod agonists facilitate TWAA acquisition due to its anxiolytic-like effects rather than just because its/their locomotor-enhancing effects.
Cholecystokinin octapeptide induces endogenous opioid-dependent anxiolytic effects in morphine-withdrawal rats
2014, NeuroscienceCitation Excerpt :The presence of CCK receptors in opioid-containing neurons suggests a potential direct interaction between opioids and the CCK system. CCKs and opioids play antagonistic roles in various biological and behavioral processes, as well as in anxiety (Koks et al., 1998, 1999). However, earlier studies have failed to demonstrate an affinity of CCK for opioid receptors, indicating that CCK does not behave as a classical receptor antagonist via binding to opioid receptors (Wang et al., 1989; Wang and Han, 1990).
The effect of opiodergic system and testosterone on anxiety behavior in gonadectomized rats
2014, Behavioural Brain ResearchCitation Excerpt :The anxiolytic-like response of morphine may be mediated by activation of μ-opioid receptor. The results are consistent with other investigations that showed an anxiolytic-like response for morphine following systemic [43–45], intracerebroventricular [46], intra-ventral hippocampal or intra-nucleus accumbal administration [26]. Some investigation reported that morphine indicate an anxiolytic response through increasing the time spent in open arms, decreasing in the time spent in closed arms and increasing open arm entries in the EPM [46,47].
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Correspondence to:Dr Sulev Kõks, Department of Physiology, University of Tartu, 2 Näituse Street, EE2400 Tartu, Estonia. Tel: 372 7 37433; Fax: 372 7 374332; E-mail: sulev. [email protected]