Original researchRelationship Between Serum Carnitine, Acylcarnitines, and Renal Function in Patients With Chronic Renal Disease
Section snippets
Methods
This study was performed in 2 parts in patients with chronic kidney disease and in healthy volunteers. Part A was performed at the Hôpital Edouard Herriot in Lyon, France, and part B was performed at Harbor-UCLA Medical Center in Torrance, California. We examined the relationship between serum free carnitine and acylcarnitines in 65 subjects with chronic kidney disease (CKD), 29 patients undergoing MHD, and 20 normal healthy individuals (Table 1). All subjects and patients were enrolled on a
Results
Characteristics of the subjects are shown in Table 1. In study A, the MHD patients were slightly but significantly older than the CKD or normal control subjects. There were no differences in age among the CKD, MHD, and normal individuals in study B. The GFR in the two groups of CKD patients combined in studies A and B averaged 43.2 ± 17.7 mL/min/1.73 m2, range 7 to 77, and was not different in study A versus study B. Gender distribution was similar in the CKD and MHD patients and normal
Discussion
The results of this cross-sectional study indicate that in individuals with CKD and in normal controls, serum total and free carnitine do not vary as the GFR decreases over a range of GFR values of 85 to 7 mL/min/1.73 m2. By contrast, in MHD patients, who had the lowest level of renal function, serum free carnitine was significantly lower and serum acylcarnitine was greater as compared with the normal control values.
These results suggest that the lower serum free carnitine in MHD patients is
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Study part A was partly supported by the University Claude Bernard Lyon 1, and Hospices Civils de Lyon, France. Study part B was partly funded through a grant from Sigma-Tau Corporation, and a National Institutes of Health grant M01-RR-00425 (GCRC, Harbor-UCLA Medical Center, Torrance, CA). Dr. Nakamura was supported by Hospal Corporation, Japan.