Original investigationDialysis therapyHistory of Cardiovascular Disease Is Associated With Endothelial Progenitor Cells in Peritoneal Dialysis Patients
Section snippets
Design and Patients
We performed a cross-sectional study of 38 consecutive peritoneal dialysis patients at the University Hospital of Vienna, Austria. The Ethical Review Board at the University of Vienna approved the study. All patients provided written informed consent.
Participants had to be clinically stable, older than 18 years, treated with peritoneal dialysis for at least 3 months, and free from peritonitis within 2 months before the study began. Exclusion criteria were overtreatment with erythropoietin
Patients and Cardiovascular Disease Risk Factors
Important demographic and clinical characteristics, as well as biochemical data for the 38 patients, are listed in Table 1. Four patients had a failed kidney graft. Thirty-six patients were treated for arterial hypertension (8 patients, angiotensin II receptor blockers; 16 patients, angiotensin-converting enzyme inhibitors; 6 patients, both classes of antihypertensives), 21 patients had uncontrolled hypertension (systolic and/or diastolic blood pressure ≥ 130 mm Hg and/or ≥ 80 mm Hg), and 35
Discussion
In this first study of the association of EPCs with cardiovascular disease risk factors in patients with end-stage renal disease, we found an inverse association of history of vascular disease with EPC number in erythropoietin-treated peritoneal dialysis patients, whereas this was not the case for other conventional cardiovascular disease risk factors. We observed no association of endothelial-dependent and endothelial-independent forearm blood flow reactivity with either circulating or
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Originally published online as doi:10.1053/j.ajkd.2005.05.015 on July 22, 2005.
Supported in part by a research grant from the Major of Vienna and institutional revenue.
S.S., A.V., M.W., and G.S.-P. created the concept and design of this study; S.S., J.G., and C.W.K. performed endothelial progenitor cell measurements; G.S. performed forearm blood flow measurements and statistical analyses; H.P. and M.F. were responsible for collection of patient and laboratory data; S.S., G.S., M.F., M.W., and G.S.-P. took part in analysis and interpretation of data; S.S. and G.S.-P. contributed to drafting of the manuscript; and S.S., G.S., M.F., A.V., M.W., E.M., W.H.H., and G.S.-P. performed critical revision of the manuscript for important intellectual content.