Elsevier

Human Pathology

Volume 32, Issue 8, August 2001, Pages 889-892
Human Pathology

Case Studies
Intrathyroidal water-clear cell parathyroid adenoma: A case report*

https://doi.org/10.1053/hupa.2001.26478Get rights and content

Abstract

Adenomas of the parathyroid gland, the majority of which contain mixed cell populations, are the most frequent cause of primary hyperparathyroidism. Parathyroid adenomas composed exclusively of water-clear cells are exceptionally rare. Until now, only 2 cases have been reported in English literature. We report a water-clear cell adenoma of the parathyroid gland in an intrathyroidal position, which has not been described previously according to our knowledge. HUM PATHOL 32:889-892. Copyright © 2001 by W.B. Saunders Company

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Case report

A 43-year-old woman was admitted to Osmangazi University Department of Orthopedia for bilateral femoral neck fracture. After review of systems, she was noted to have difficulty in walking, leg cramps, progressive tiredness, and lethargy of approximately 3 years duration. Laboratory evaluation by the Department of Endocrinology revealed a serum calcium level of 13.3 mg/dL (reference range 9-11 mg/dL), serum phosphorus level of 1.5 mg/dL (reference range 2.7-4.5 mg/dL), and serum parathyroid

Discussion

The embroyologic development of the thyroid and parathyroid is well known. Although the superior parathyroid glands originate in the epithelium of the dorsal portion of the fourth pharyngeal pouch, the inferior parathyroid glands originate from the epithelium of the dorsal portion of the third pharyngeal pouch.5

Related with embroyologic migration patterns, abnormal parathyroid tissues can occur in ectopic locations. Ectopic locations include the superior mediastinum, within the thymus and

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*

Address correspondence and reprint requests to Emine Dundar, Osmangazi Universitesi, Tip Fakültesi Patoloji, Anabilim Dali 26480, Eskişehir-Turkey.

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Copyright © 2001 W.B. Saunders Company. Published by Elsevier Inc. All rights reserved.