Case StudiesIntraglomerular microlesions in renal angiomyolipoma
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Stimulator of interferon genes (STING) immunohistochemical expression in the spectrum of perivascular epithelioid cell (PEC) lesions of the kidney
2021, PathologyCitation Excerpt :Both inherited and most sporadic angiomyolipomas demonstrate loss of heterozygosity and mutation of chromosome 16p (TSC2).15,16 Intraglomerular PEC lesions have been reported in patients with tuberous sclerosis and in the TSC2/PKD1 contiguous gene syndrome.17,18 Also, AMLEC has been found in patients with and without tuberous sclerosis.19
Angiomyolipoma of the kidney: from simple hamartoma to complex tumour
2021, PathologyCitation Excerpt :When there are extremely numerous merging lesions occupying a large amount of the renal parenchyma, the macroscopic appearance may resemble an infiltrative mass. Intraglomerular lesions, first described by Ferez in 1930 as epithelial and fatty inclusions in the glomerulus, consist of minute nodules composed of epithelioid smooth muscle cells occasionally intermixed with a few adipocytes within the glomerular capillary tuft30,31 (Fig. 5). They have been reported sporadically or in patients with tuberous sclerosis and in the TSC2/PKD1 contiguous gene syndrome, a disease with a deletion disrupting both TSC2 and PKD1 (autosomal dominant polycystic disease gene).32
Potential Risks of Stem Cell Therapies
2011, Regenerative NephrologyNeoplasms of the kidney
2008, Urologic Surgical Pathology: Second EditionRenal pathology in the tuberous sclerosis complex
2003, Pathology