Enhancement of Mammographic–Pathologic Correlation Utilizing Large Format Histology for Malignant Breast Disease
Section snippets
Radiologic–Pathologic Correlation
Radiologic–pathologic correlation in this paper will be approached by comparing some of the most commonly seen mammographic and ultrasound abnormalities with corresponding pathologic findings. Breast imaging abnormalities can be roughly divided into three main categories: mass lesions, calcifications, and architectural distortion. There is significant overlap among demonstration of these abnormalities and three main pathologic malignant breast lesions: infiltrating ductal carcinoma (IDCA),
Case Discussions
In this section, we will use some of our cases with large format histology to demonstrate the radiologic pathologic correlation for the different patterns of lesions described above.
Case #1 (Fig. 2) is a 71-year-old woman who presented with a palpable mass in her left breast and crushed stone and casting type calcifications on her mammogram (Fig. 2A). An associated widespread area of altered echogenicity and calcifications on breast ultrasound (Fig. 2B) correlated with the palpable mass and
Conclusion
Large format histology has proven to be a useful technique to enhance radiologic-pathologic correlation of malignant breast disease. The large format technique offers advantages related to the contiguous sampling of large areas of tissue and subsequent correlation with radiologic images. This activity may enhance multidisciplinary understanding of breast cancer and promote the team approach to optimum patient care.
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Can we improve breast cancer management using an image-guided histopathology workup supported by larger histopathology sections?
2023, European Journal of RadiologyBreast cancer multifocality, disease extent, and survival
2011, Human PathologyCitation Excerpt :Large-format histopathology, used routinely in only a few laboratories, has gained increasing attention as the only histopathology method addressing the need for radiologic/pathologic correlation in this era of multimodality breast imaging. In addition, large-format histopathology documents the subgross morphology of breast carcinoma much more accurately than the conventional histopathology approach [10-12]. In this article, we present long-term follow-up results from a series of breast carcinoma cases, describing the prognostic significance of lesion distribution and disease extent documented in large-format histopathology slides.
Cost-benefit analysis of using large-format histology sections in routine diagnostic breast care
2010, BreastCitation Excerpt :As modified and used in our13–15 and other laboratories,12,16–18 large-format histopathology combines the advantages of whole organ sectioning (with substantially reduced turn-around time and cost) with the advantages of the conventional small block technique, making the large-format technique sufficient for meeting the needs of oncologic therapy planning while allowing proper documentation of “radiological–surgical” parameters. In addition, it is an ideal tool for radio-pathologic correlations13,15,19,20 and for multidisciplinary evaluation of cases during tumor board meetings.13–15,21 Radiology techniques have much lower resolution capacity than do microscopic methodologies, but provide an excellent overview of the normal tissue and the lesions within it and, as such, correspond more to the morphologic method of the whole organ studies than to the conventional small block methods used in most diagnostic pathology laboratories.
The metastatic capacity of multifocal breast carcinomas: extensive tumors versus tumors of limited extent
2009, Human PathologyCitation Excerpt :The present study also confirmed the high metastatic capacity of these tumors because they exhibited a substantially higher risk of having positive lymph nodes compared with extensive unifocal tumors (odds ratio, 9.9) as well as with unifocal tumors of limited extent (odds ratio, 12.5813). Finally, the present study indicates the suitability of the large-section histopathology technique to document the extent and distribution of lesions in breast carcinomas, similar to a series of previous studies [22-25]. In conclusion, most breast carcinomas are multifocal because of multiple in situ or multiple invasive foci or both.
Large-format histology in diagnosing breast carcinoma
2020, Vojnosanitetski Pregled