System theoretical investigation of human epidermal growth factor receptor-mediated signalling
System theoretical investigation of human epidermal growth factor receptor-mediated signalling
- Author(s): Y. Zhang ; H. Shankaran ; L. Opresko ; H. Resat
- DOI: 10.1049/iet-syb:20080116
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- Author(s): Y. Zhang 1 ; H. Shankaran 1 ; L. Opresko 2 ; H. Resat 1
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View affiliations
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Affiliations:
1: Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland, USA
2: Cell Biology and Biochemistry Group, Pacific Northwest National Laboratory, Richland, USA
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Affiliations:
1: Computational Biology and Bioinformatics Group, Pacific Northwest National Laboratory, Richland, USA
- Source:
Volume 2, Issue 5,
September 2008,
p.
273 – 284
DOI: 10.1049/iet-syb:20080116 , Print ISSN 1751-8849, Online ISSN 1751-8857
The partitioning of biological networks into coupled-functional modules is being increasingly applied for developing predictive models of biological systems. This approach has the advantage that predicting a system-level response does not require a mechanistic description of the internal dynamics of each module. Identification of the input–output characteristics of the network modules and the connectivity between the modules provide the necessary quantitative representation of system dynamics. However, the determination of the input–output relationships of the modules is not trivial; it requires the controlled perturbation of module inputs and systematic analysis of experimental data. In this report, the authors apply a system theoretical analysis approach to derive the time-dependent input–output relationships of the functional module for the human epidermal growth factor receptor (HER) mediated Erk and Akt signalling pathways. Using a library of cell lines expressing endogenous levels of epidermal growth factor receptor (EGFR) and varying levels of HER2, the authors show that a transfer function-based representation can be successfully applied to quantitatively characterise information transfer in this system. [Includes supplementary material]
Inspec keywords: skin; neurophysiology; cellular biophysics
Other keywords:
Subjects: Biological transport; cellular and subcellular transmembrane physics; External and internal data communications, nerve conduction and synaptic transmission
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