Elsevier

Kidney International

Volume 59, Supplement 78, February 2001, Pages S195-S196
Kidney International

Cellular Immune Defects in Uremia
Dysfunction of polymorphonuclear leukocytes in uremia: Role of parathyroid hormone

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Dysfunction of polymorphonuclear leukocytes in uremia: Role of parathyroid hormone. Polymorphonuclear leukocytes (PMNLs) from uremic patients have elevated basal levels of cytosolic calcium ([Ca2+]i), reduced calcium signal after activation of Fcγ RIII receptor, and impaired phagocytosis. Chronic excess of parathyroid hormone (PTH) in uremia mediates its effect on PMNL's metabolism and function through the sustained elevation of their [Ca2+]i. Because calcium channel blockers interfere with this effect of PTH on PMNLs, treatment of patients on hemodialysis with verapamil, nifedipine, or amlodipine was associated with an improvement in metabolism and phagocytosis of PMNLs in humans. The therapy with calcium channel blockers should be continued in order to maintain its beneficial effects.

Keywords

chronic renal disease
calcium channel blockers
hemodialysis
bacterial infection

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