Elsevier

Differentiation

Volume 59, Issue 5, February 1996, Pages 269-282
Differentiation

Review article
Stage-specific and cell type-specific aspects of genomic imprinting effects in mammals

https://doi.org/10.1046/j.1432-0436.1996.5950269.xGet rights and content

Abstract

Recent studies have revealed that maternal and paternal alleles of some imprinted genes are differentially expressed from the earliest time of expression, with virtually no expression from one of the two alleles, while for other imprinted genes the normally silent allele can be transcribed during early development. In addition, a number of imprinted genes manifest their imprints only in select tissues. These observations indicate that the marks that denote parental chromosome origin need not directly determine allele expression, but rather bias later epigenetic modifications toward a particular allele. Thus, factors expressed at specific stages or in specific cell types are required to silence one parental allele or another. Stage-dependent and tissue-specific epigenetic modifications include the progressive establishment of the mature adult parental allele-specific DNA methylation patterns. These changes resemble and may share a common mechanistic basis with other epigenetic modifications that occur during development. Understanding the mechanisms by which these post-fertilization epigenetic modifications are mediated and regulated will be essential for understanding how genomic imprinting leads to differences in parental allele expression.

References (147)

  • KE Latham et al.

    Stage-specific induction and regulation by genomic imprinting of the mouse U2afbp-rs gene during preim-plantation development

    Dev Biol

    (1995)
  • S Malcolm et al.

    Uniparental-paternal disomy in Angelmann's syndrome

    Lancet

    (1991)
  • J McGrath et al.

    Completion of mouse embryogenesis requires both maternal and paternal genomes

    Cell

    (1984)
  • T Moore et al.

    Genomic imprinting in mammalian development: a parental tug-of-war

    Trends Genet

    (1991)
  • DP Norris et al.

    Evidence that random and imprinted Xist expression is controlled by preemptive methylation

    Cell

    (1994)
  • M Ariel et al.

    Gamete-specific methylation correlates with imprinting of the murine Xist gene

    Nature Genet

    (1995)
  • PA Baldacci et al.

    The locus Om, responsible for the DDK syndrome, maps close to Sigje on mouse chromosome 11

    Mammalian Genome

    (1992)
  • DP Barlow et al.

    The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus

    Nature

    (1991)
  • MS Bartolomei et al.

    Parental imprinting of the mouse H19 gene

    Nature

    (1991)
  • SC Barton et al.

    Development of gynogenetic and parthenogenetic inner cell mass and trophectoderm tissues in reconstituted blastocysts in the mouse

    J Embryol Exp Morphol

    (1985)
  • SC Barton et al.

    Role of paternal and maternal genomes in mouse development

    Nature

    (1984)
  • C Babinet et al.

    The DDK inbred strain as a model for the study of interactions between parental genomes and egg cytoplasm in mouse preim-plantation development

    Development

    (1990)
  • M Brandeis et al.

    The ontogeny of allele-specific methylation associated with imprinted genes in the mouse

    EMBO J

    (1993)
  • N Brockdorff et al.

    The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus

    Cell

    (1992)
  • AJ Buckler et al.

    Isolation, characterization, and expression of the murine Wilms' tumor gene (WTI) during kidney development

    Mol Cell Biol

    (1991)
  • S Casola et al.

    Loss of heterozygosity of imprinted genes in SV40 t/T antigen-induced hepatocellular carcinoma

    Oncogene

    (1995)
  • BM Cattanach

    Position effect variegation in the mouse

    Genet Res

    (1974)
  • BM Cattanach

    Parental origin effects in mice

    J Embryol Exp Morphol

    (1986)
  • BM Cattanach

    Mammalian chromosome imprinting

    Genome

    (1989)
  • BM Cattanach et al.

    A candidate mouse model for Prader-Willi syndrome which shows an absence of Snrpn expression

    Nature Genet

    (1992)
  • BM Cattanach et al.

    Autosomal and X-chromosome imprinting

    Development

    (1990)
  • BM Cattanach et al.

    Differential activity of maternally and paternally derived chromosome regions in mice

    Nature

    (1985)
  • L-Y Chao et al.

    Genetic mosaicism in normal tissues of Wilms' tumor patients

    Nature Genet

    (1993)
  • B Christofori et al.

    A second signal supplied by insuline-like growth factor II in oncogene-induced tumorigenesis

    Nature

    (1994)
  • J Clayton-Smith et al.

    Maternal origin of deletion 15qll-13 in 25/25 cases of Angelman syndrome

    Hum Genet

    (1992)
  • HV Crouse

    The controlling element in sex chromosome behavior in Sciara

    Genetics

    (1960)
  • SM Davies

    Developmental regulation of genomic imprinting of the IGF2 gene in human liver

    Cancer Res

    (1994)
  • TM DeChiara et al.

    A growth- deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

    Nature

    (1990)
  • MJ Donoghue et al.

    An axial gradient of transgene methylation in murine skeletal muscle: Genomic imprint of rostrocaudal position

    Development

    (1992)
  • MJ Donaghue et al.

    Rostrocaudal gradient of transgene expression in adult skeletal muscle

    Proc Nat Acad Sci USA

    (1991)
  • SF Dowdy et al.

    Suppression of tumorigenicity in Wilms tumor by the p15.5–p14 region of chromosome II

    Science

    (1991)
  • R Feil et al.

    Developmental control of allelic methylation in the imprinted mouse Igf2 and H19 genes

    Development

    (1994)
  • AP Feinberg

    Genomic imprinting and gene activation in cancer

    Nature Genet

    (1993)
  • U Francke et al.

    Aniridia-Wilms' tumor association: evidence for specific deletion of 11p13

    Cytogenet Cell Genet

    (1979)
  • R Fundele et al.

    Developmental potential of parthenogenetic cells: role of genotype-specific modifiers

    Development

    (1991)
  • N Giannoukakis et al.

    Parental genomic imprinting of the human IGF2 gene

    Nature Genet

    (1993)
  • SJ Giddings et al.

    Allele specific inactivation of insulin 1 and 2, in the mouse yolk sac, indicates imprinting

    Nature Genet

    (1994)
  • T Glaser et al.

    A mouse model of the aniridia-Wilms tumor deletion syndrome

    Science

    (1990)
  • CC Glenn et al.

    Functional imprinting and epigenetic modification of the human SNRPN gene

    Hum Mol Genet

    (1993)
  • F Guillemot et al.

    Genomic imprinting of Mush-2, a mouse gene required for trophoblast development

    Nature Genet

    (1995)
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