Synapse proteomics has recently resulted in a quantum leap in knowledge of the protein composition of brain synapses and its phosphorylation. We now have the first draft picture of the synapse, comprising ∼1000 proteins. This is not matched by available methods of functional analysis either in reduced systems or in whole animals. Fewer than 20% of synapse proteome proteins have a known function in the nervous system. A concerted effort is required to establish new technical approaches before we can understand the diversity of functions conferred by the synapse proteome on the synapse, the neuron and the animal. This review will highlight this change in knowledge and discuss current technical and interpretative limitations challenged by synapse proteomics.
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February 2006
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Conference Article|
January 20 2006
The synapse proteome and phosphoproteome: a new paradigm for synapse biology
S.G.N. Grant
S.G.N. Grant
1
1Genes to Cognition Programme, Wellcome Trust Sanger Institute, Cambridge CB10 1SA, U.K.
1 email sg3@sanger.ac.uk
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Publisher: Portland Press Ltd
Received:
September 02 2005
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (1): 59–63.
Article history
Received:
September 02 2005
Citation
S.G.N. Grant; The synapse proteome and phosphoproteome: a new paradigm for synapse biology. Biochem Soc Trans 1 February 2006; 34 (1): 59–63. doi: https://doi.org/10.1042/BST0340059
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