Treatment of female rats with ethynyloestradiol decreased both the activity of carnitine palmitoyltransferase and its Ki value for malonyl-CoA compared with pair-fed control rats. In starved rats, carnitine palmitoyltransferase activity and its Ki value for malonyl-CoA were both elevated as expected. Oestrogen treatment had no effect on carnitine palmitoyltransferase activity in the starved state, but the Ki value for malonyl-CoA was substantially decreased by oestrogen. Treatment with a more physiological concentration of ethynyloestradiol (15 micrograms/kg body wt. per day) also produced a decrease in the Ki value for malonyl-CoA. These data suggest that the oestrogen may produce its anti-ketogenic effect by increasing the affinity of carnitine palmitoyltransferase for its physiological inhibitor, malonyl-CoA.
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July 1986
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Research Article|
July 15 1986
Regulation by oestrogen of carnitine palmitoyltransferase in hepatic mitochondria
Publisher: Portland Press Ltd
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© 1986 London: The Biochemical Society
1986
Biochem J (1986) 237 (2): 593–596.
Citation
I Weinstein, G A Cook, M Heimberg; Regulation by oestrogen of carnitine palmitoyltransferase in hepatic mitochondria. Biochem J 15 July 1986; 237 (2): 593–596. doi: https://doi.org/10.1042/bj2370593
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