SCHEDULED MAINTENANCE
The first stereospecific chemical synthesis of a sample of the amino acid (2S)-leucine labelled in one of the diastereotopic methyl groups has been achieved using (2S)-pyroglutamic acid as a chiral template. This has been used to develop a method for assigning resonances to the diastereotopic methyl groups of the leucine residues in the 1H NMR spectra of proteins.
R. A. August, J. A. Khan, C. M. Moody and D. W. Young, J. Chem. Soc., Perkin Trans. 1, 1996, 507 DOI: 10.1039/P19960000507
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