Issue 9, 1995
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Penitremones A–C, Penicillium metabolites containing an oxidised penitrem carbon skeleton giving insight into structure–tremorgenic relationships

Jyotigna T. Naik,   Peter G. Mantle,   Richard N. Sheppard  and  Eric S. Waight  

Abstract

A new group of microbial metabolites, designated penitremones A–C, have been characterised by mass spectrometry and 1H and 13C NMR spectroscopy as 10-keto, 11,33-dihydro-variants of the penitrem indole-isoprenoid skeleton. The principal metabolite penitremone A, produced with penitrem A by a Penicillium sp., is an isomer of penitrem E and was also similarly tremorgenic. Reduction of the carbonyl of penitremones A and B with NaHB4 altered tremorgenic activity, thereby indicating potential for new insights into structure–activity relationships in tremorgenic mycotoxins, particularly with respect to neurological disorders in agricultural ruminants caused by the related keto-alkaloid lolitrem B.

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Article information

DOI
https://doi.org/10.1039/P19950001121
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1995, 1121-1125

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Penitremones A–C, Penicillium metabolites containing an oxidised penitrem carbon skeleton giving insight into structure–tremorgenic relationships

J. T. Naik, P. G. Mantle, R. N. Sheppard and E. S. Waight, J. Chem. Soc., Perkin Trans. 1, 1995, 1121 DOI: 10.1039/P19950001121

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