Issue 0, 1971
From the journal:

Journal of the Chemical Society C: Organic

Polypeptides. Part XV. The synthesis and oxidation of some L-cysteinylpolyglycyl-L-cysteines

P. M. Hardy,   B. Ridge,   H. N. Rydon  and  F. O. dos S. P. Serrão  

Abstract

S-Benzyl-N-benzyloxycarbonyl-L-cysteinyl-hepta-, -octa-, -nona-, -dodeca-, and -pentadeca-glycyl-S-benzyl-L-cysteine benzyl esters (IV; n= 7, 8, 9, 12, or 15) have been synthesised. The oxidation, in aqueous solution at pH 8·5, of the L-cysteinylpolyglycyl-L-cysteines (I; n= 7, 8, 9, 12, or 15) derived from these by removal of the protecting groups, and of two lower members of the series (I; n= 4 or 5), has been studied. It is shown that in all these cases the composition of the oxidation product, in particular the amount of cyclic monomeric disulphide (II) present, is close to that predicted by a simple statistical theory.

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Article information

DOI
https://doi.org/10.1039/J39710001722
Article type
Paper

J. Chem. Soc. C, 1971, 1722-1731

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Polypeptides. Part XV. The synthesis and oxidation of some L-cysteinylpolyglycyl-L-cysteines

P. M. Hardy, B. Ridge, H. N. Rydon and F. O. D. S. P. Serrão, J. Chem. Soc. C, 1971, 1722 DOI: 10.1039/J39710001722

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