Issue 0, 1971

The synthesis and properties of bradykinin analogues: 1-deamino-, 9-decarboxy-, and 1-deamino-9-decarboxy-bradykinin

Abstract

A new synthesis of bradykinin (1) has been developed and adapted to the synthesis of three new analogues of bradykinin, viz. 1-deamino-, 9-decarboxy-, and 1-deamino-9-decarboxy-bradykinin. The biological activities of these analogues have been determined; they demonstrate that the terminal carboxy-group is very important for kinin-like activity whereas the terminal amino-group is less so.

Article information

Article type
Paper

J. Chem. Soc. C, 1971, 748-753

The synthesis and properties of bradykinin analogues: 1-deamino-, 9-decarboxy-, and 1-deamino-9-decarboxy-bradykinin

W. H. Johnson, H. D. Law and R. O. Studer, J. Chem. Soc. C, 1971, 748 DOI: 10.1039/J39710000748

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